Tamoxifen Citrate Anti Estrogen Steroids Nolvadex Dosage for Bodybuilding
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|FOB Unit Price:||US $1 US $0.9 US $0.6 US $0.4|
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- Model NO.: CAS 54965-24-1
- Customized: Non-Customized
- Suitable for: Elderly, Children, Adult
- Purity: >99%
- Usage: Progesteron. It Was Isolated From Adrenal Glands
- Usage 3: a Metabolite of Progesterone
- Transport Package: Shipping by Drum or Send by Discreet Parcel
- Origin: China
- Powder: Yes
- Certification: GMP, ISO 9001, USP, BP
- State: Powder
- CAS: 68-96-2
- Usage 2: Anticoagulant
- Trademark: LSW
- Specification: USP
- HS Code: 8888
|Product Name:||Tamoxifen Critrate||Other names||Tamoxifen Critrate tabs, nolvadex, Tamoxifen Citrate, TAM|
|Einecs No:||234-118-0||Usage:||Anti Estrogen Steroids|
What is Tamoxifen Critrate or nolvadex anti estrogen steroids?
In other tissues such as theendometrium,
it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen Critrate is the usual endocrine(anti-estrogen) therapy for hormone
receptor-positive breast cancer in pre-menopausal women, and is also a standard
in post menopausal women although aromatase inhibitors are also frequently used
in that setting.
Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen Critrate is metabolized into compounds that also bind to the estrogen receptor but do not activate it. Because of this competitive antagonism, tamoxifen Critrate acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
Benefits of Tamoxifen Critrate
A. Tamoxifen Critrate slows or stops the growth of cancer cells that are already present in the body. It helps keep the original breast cancer from coming back and helps prevent new cancer in the opposite breast. It also reduces the risk of breast cancer in women who have a high risk for this disease.
B. Tamoxifen Critrate is used to prevent and treat breast cancers that test positive for estrogen receptors (ER+). It blocks the effects that the hormone estrogen has on cancer cells and lowers the chance that breast cancer will grow. It is often called an "anti-estrogen."
C. Tamoxifen Critrate is highly effective in lowering the risk of breast cancer recurrence. In women who have already had breast cancer, tamoxifen Critrate also lowers
the risk of breast cancer in the opposite breast (contralateral)
D. For postmenopausal women, a two-stage treatment using tamoxifen Critrate and then an aromatase inhibitor, such as anastrozol (Arimidex), exemestan(Aromasin), or letrozol (Femara) may work better
than only taking tamoxifen Critrate.
The truth about Tamoxifen Critrate Nolvadex
It is not correct that Nolvadex reduces levels of estrogen: rather, it blocks estrogen
from estrogen receptors and, in those tissues where it is an antagonist, causes the
receptor to do nothing.
The claim that Nolvadex reduces gains should not be taken too seriously. The fact is that any number of bodybuilders have made excellent gains while using Nolvadex.
The belief that it reduces gains seems to stem from the fact that the scientific literature reports a slight reduction in IGjF-1 (individuals using anabolic steroids were not
studied though) from use of Nolvadex.Thus, Dan Duchaine reported that it reduces IGjF1 and therefore reduces gains. However, if this effect exists at all, it must be very minor, due to the excellent gains that many have made, and from the fact that no one has noticed any such thing from Clomid, which has the same activity profile.
The fact that Nolvadex will reduce water retention may result in the user agreeing
that gains are less, since weight gain is less, thus reinforcing the bias.
Tamoxifen Critrate Application:
Tamoxifen Critrate is currently used for the treatment of both early and advanced ER+ (estrogen receptor positive) breast cancer in pre- and post-menopausalwomen.
Additionally, it is the most common hormone treatment for male breast cancer. It is also approved by the FDA for the prevention of breast cancer in women at high risk of developing the disease. It has been further approved for the reduction of contralateral (in the opposite breast) cancer. The use of tamoxifen Critrate is recommended for 10 years.
In McCune-Albright syndrome (MAS) tamoxifen citrate has been used to treat
premature puberty and the consequences of premature puberty. Tamoxifen citrate
has been seen to decrease rapid bone maturation which is the result of excessive
estrogen and alter predicted adult height (PAH). The same effects have also been
seen in short pubertal boys.
However, one in vitro study in 2007 and later an in vivo study in 2008 have shown
that tamoxifen citrate induces apoptosis in growth plate chondrocytes, reduces
serum IGlF-I levels and causes persistent retardation of longitudinal and cortical
radial bone growth in young male rats, leading the researches to express concern
giving tamoxifen Critrate to growing individuals.
Tamoxifen citrate is used to treat infertility in women with anovulatory disorders. A dose of 10-40 mg per day is administered in days 3-7 of a woman's cycle. In
addition, a rare condition occasionally treated with tamoxifen Critrate is retroperitoneal fibrosis.
Tamoxifen citrate is used to prevent estrogen-related gynecomastia, resulting from
elevated estrogenic levels. It is taken as a preventative measure in small doses, or used at the onset of any symptoms such as nipple soreness or sensitivity. Other
drugs are taken for similar purposes such as clomiphene citrate and the anti-aromatase drugs which are used in order to try to avoid the hormone related adverse effects. Tamoxifen Critrate is also sometimes used to treat or prevent gynecomastia in sex offenders undergoing temporary chemical castration.
Tamoxifen citrate has been shown to be effective in the treatment of mania in patients with bipolar disorder by blocking protein kinase C (PKC), an enzyme that regulates neuron activity in thebrain. Researchers believe PKC is over-active during the
mania in bipolar patients.
Angiogenesis and cancer
Tamoxifen citrate is one of three drugs in an anti-angiogenetic protocol developed
by Dr. Judah Folkman, a researcher at Children's Hospital at Harvard Medical
School in Boston. Folkman discovered in the 1970s that angiogenesis - the growth of new blood vessels - plays a significant role in the development of cancer. Since
his discovery, an entirely new field of cancer research has developed. Clinical trials on angiogenesis inhibitors have been underway since 1992 using myriad different drugs. The Harvard researchers developed a specific protocol for a golden retriever named Navy who was cancer-free after receiving the prescribed cocktail and tamoxifen Critrate - the treatment subsequently became known as the Navy Protocol. Furthermore tamoxifen Critrate treatment alone has
been shown to have anti-angiogenetic effects in animal models of cancer which
appear to be, at least in part, independent of tamoxifen citrate's estrogen receptor antagonist properties.
Control of gene expression
Tamoxifen citrate is used as a research tool to trigger tissue-specific gene
expression in many conditional expression constructs in genetically modified animals including a version of the Cre-Lox recombination technique.
Tamoxifen citrate has been proposed as part of a treatment plan for Riedel's thyroiditis.
Tamoxifen citrate anti estrogen steroids nolvadex dosage for bodybuilding 54965-24-1
Alias: Nolvadex; TAM,Tamoxifen citrate, tamoxifen citrate tabs
CAS No: 54965-24-1
Einecs No: 234-118-0
Category: weight loss steroids
Appearance: White powder
Storage: Shading, confined preservation
Usage: anti estrogen steroids, treatment for breast cancer, weight gain, bodybuilding, pct cycle
Tamoxifen citrate COA reviews:
|Characteristics||White crystalline powder||conforms|
|Assay||99 ~ 101.0%||99.51%|
|Loss on drying||≤0.5%||0.24%|
|Residue on ignition||≤0.2%||0.06%|
|Organic volatile impurities||conform||conform|
|Conclusion||This batch is complies with USP 30.|
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