Goserelin Acetate White Powder CAS: 145781-92-6 for Treating Breast Cancer
|FOB Unit Price:||US $5 US $3|
|Purchase Qty. (g)||FOB Unit Price|
|Port:||Hong Kong, Hong Kong|
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- Model NO.: 145781-92-6
- Customized: Non-Customized
- Suitable for: Adult
- Purity: >99%
- MW: 1269.41
- Transport Package: Discreet Package
- Origin: China
- Powder: Yes
- Certification: GMP, ISO 9001, USP
- State: Solid
- Mf: C59h84n18o14
- Trademark: LSW
- Specification: USP, BP
- HS Code: 2906131000
Goserelin acetate White Powder CAS: 145781-92-6 for Treating Breast Cancer
Goserelin (INN, USAN, BAN) (brand name Zoladex, by AstraZeneca), or goserelin acetate,is a drug used to suppress production of the sex hormones (testosterone and estrogen), particularly in the treatment of breast and prostate cancer. It is an injectable gonadotropin releasing hormone superagonist (GnRH agonist), also known as a luteinizing hormone releasing hormone (LHRH) agonist.
|Product name||Goserelin acetate|
|CAS No.||145781-92-6||Outer Packing||10g/100g|
|Production date||161221||Shelf life||2 years|
|Items of analysis||Specification||Results|
|Appearance||White or almost white powder||Conforms|
|Solubility||Soluble in water,freely soluble in glacial acetic acid.It dissolves||Conforms|
Goserelin acetate stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production.
Zoladex was approved by the U.S. Food and Drug Administration in 1989 for treatment of prostate cancer.
Indications and Usage:
Palliative treatment of advanced carcinoma of the prostate; in combination with flutamide for management of locally confined stage T2b to T4 (stage B2 to C) carcinoma of the prostate.
Women (3.6 mg only)
Palliative treatment of advanced breast cancer in pre- and perimenopausal women; treatment of endometriosis; as an endometrial thinning agent prior to endometrial ablation for dysfunctional uterine bleeding.
Known hypersensitivity to GnRH, GnRH agonist analogues, or any of the components in goserelin; pregnancy unless goserelin is being used for palliative treatment of advanced breast cancer.
Mechanism of Action:
Goserelin acetate is an anti-cancer drug, classified as an analog of naturally occurring luteinizing hormone-releasing hormone (LHRH), and it is used for the treatment of prostate cancer, breast cancer, endometriosis, and abnormal bleeding of the uterus. "The acetate salt of a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH). Continuous, prolonged administration of goserelin in males results in inhibition of pituitary gonadotropin secretion, leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production," note the National Cancer Institute (NCI) Drug Dictionary.
Both breast and prostate cancer are the second most common types of cancer among women and men respectively, and its growth is often promoted by sex hormones. Therefore, the mechanism of action of goserelin acetate is based on interfering with these hormones to decrease their amount in the body and stop cancer growth. Goserelin acetate is available as an implant that is inserted by a doctor or nurse with a syringe subcutaneously in the area of the stomach. Depending on the patient's needs and disease, the implant can have 3.6 mg of goserelin inserted every four weeks or 10.8 mg of goserelin to be implanted every 12 weeks. The length of the treatment also depends on the condition being treated and patient's response to the medication.
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